PTPRC(Protein Tyrosine Phosphatase Receptor Type C)，也被称为CD45，是一种跨膜蛋白酪氨酸磷酸酶。广泛表达于T淋巴细胞、B淋巴细胞、自然杀伤细胞（NK细胞）和巨噬细胞等免疫细胞。 主要功能是通过去磷酸化作用，调节细胞内酪氨酸的磷酸化水平。在T和B淋巴细胞的激活和信号传导过程中，当T或B细胞受到外界抗原刺激时，PTPRC可以去除特定蛋白质上的磷酸化修饰，从而调节信号通路的激活和细胞应答。PTPRC在免疫调节中的作用使得它成为免疫治疗的一个重要标志物。一些免疫治疗药物利用针对PTPRC的抗体，调节免疫细胞的激活和功能，以增强免疫应答.在免疫治疗和疾病研究中具有重要的临床和科学意义。

● PTPRC Recombinant Monoclonal Antibody CSB-RA019049MA1HU

验证数据

Overlay Peak curve showing 293 cells stained with CSB-RA019049MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

PTPRC for Homo sapiens (Human)

PTPRC for H

PTPRC Proteins for Homo sapiens (Human)

PTPRC Proteins for Mus musculus (Mouse)

PTPRC Proteins for Rattus norvegicus (Rat)

PTPRC Proteins for Cyprinus carpio (Common carp)